A. Berzofsky, and P. L. Collins (2005). Family Filoviridae: Classification and features. If you are experiencing a sudden or severe change in your health, or otherwise need an immediate response, call 911 or contact your provider's office by telephone. 5): S335-S345. Special Act of Service Award, National Institute of Allergy and Infectious Diseases in Recognition and Appreciation of Special Achievement. July 21-25, 2012. The article was chosen for PNAS press release on 12/09/02. J. Virol. Dr. Alex Bukreyev at the University of Texas Medical Branch and the Galveston National Laboratory reports, “Our lab tested a panel of antibodies against a real SARS-CoV-2 in biocontainment. 80:10293-10306. B. A. Bukreyev, P. E. Rollin, M. Tate, L. Yang, S. R. Zaki, W.-J. Geisbert, A.B. 74:7151-7157. UTMB’s relationship with China dates back to 2013, when the medical branch opened discussions with three labs that were under construction, including the facility in Wuhan. U. J Buchholz, A. Bukreyev, L. Yang, E. W. Lamirande, B. R. Murphy, K. Subbarao, and P. L Collins (2004). Cell Reports 24: 1816-1829. 90(8): 3890-901. Recombinant respiratory syncytial virus (RSV) bearing a deletion of either the NS2 or SH gene is attenuated in chimpanzees. Current Opinion in Molecular Therapeutics 10(1):46-55. In their study, Alex Bukreyev, a UTMB virologist, and his team utilized ultra-deep genetic sequencing to identify how the Ebola virus adapts to bat and human cells. Granulocyte-macrophage colony-stimulating factor expressed by recombinant respiratory syncytial virus attenuates viral replication and increases the level of pulmonary antigen-presenting cells. A. Bukreyev, L. Yang, J. Fricke, L. Cheng, J. M. Ward, B. R. Murphy, and P. L. Collins (2008). G. K. Amarasinghe, N. A. Ceballos, A. C. Banyard, C. F. Basler, S. Bavari, A. J. Bennett, K. R. Blasdell, T. Briese, A. Bukreyev, Y. Cai, et al. Effect of co-expression of IL-2 by recombinant respiratory syncytial virus on virus replication, immunogenicity and production of other cytokines. 91(8):e02471-16. P. Younan, P. Ramanathan, J. Graber, F. Gusovsky, and A. Bukreyev. A. Bukreyev, S. S. Whitehead, N. Bukreyeva, B. R. Murphy, and P. L. Collins (1999). Cell Reports 24: 1802-1815. A. Ivanov, P. Ramanathan, C. Parry, P. A. Ilinykh, X. Lin, Y. Obukhov, T. Ammosova, G. K Amarasinghe, A. Bukreyev* and S. Nekhai* (2019). Neutralizing antibodies from human survivors target a conserved site in the ebolavirus glycoprotein HR2/MPER regions. (2019) Modified mRNA-based vaccines elicit robust immune responses and protect guinea pigs from Ebola virus disease. In press. M. Iampietro*, P. Younan*, A. Nishida, M. Dutta, N. M. Lubaki, R. I. Santos, R. A. Koup, M. G. Katze, and A. Bukreyev. *Co-lead authors. Virally delivered cytokines alter the immune response to future lung infections. Prince, K. C. Yim, K. K. Harris, J. A. Bukreyev, L. Yang, B. Murphy, and P. Collins (2010). National Institute of Allergy and Infectious Diseases Performance Award in Recognition of Special Achievement in Support of the Mission of the National Institute of Allergy and Infectious Diseases. M. Meyer, T. Garron, N. M. Lubaki, C. E. Mire, K. A. Fenton, C. Klages, G. G. Olinger, T. W. Geisbert, P. L. Collins, and A. Bukreyev (2015) Aerosolized Ebola vaccine protects primates and elicits lung-resident T-cell responses. Our research includes the following specific topics: To get insight into these scientific topics, we are using molecular tools, including reverse genetics (i.e. A. Bukreyev, I. M. Belyakov, J. Join Facebook to connect with Kang's Lab At Utmb and others you may know. (2017). A. I. Flyak, P. A. Ilinykh, C. D. Murin, T. Garron, X. Shen, M. L. Fusco, T. Hashiguchi, Z. Together they form a unique fingerprint. Successful topical respiratory tract immunization of primates against Ebola virus. Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors. 93(4): e01845-18. (2016) Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. 70:6634-6641. Bukreyev is the lead investigator of the funded studies conducted at UTMB. Dis. L. Yang, A. Sanchez, P. E. Rollin, B. R. Murphy, P. L. Collins, and A. Bukreyev (2008). Bombardi, M.E. (2017). Development of mucosal respiratory tract vaccines against filoviruses based on human and non-human paramyxovirus vectors. A. Bukreyev,  M. E. Serra, F. R. Laham, S. R. Kleeberger, P. L. Collins, and F. P. Polack (2006). Archives of Virology 163(8):2283-2294. P. L. Collins, S. S. Whitehead, A. Bukreyev, R. Fearns, M. N. Teng, K. Juhasz, R. M. Chanock, and B. M. Murphy (1999). Dis. 5): S418-S422. Respiratory tract immunization of primates with a Newcastle disease virus-vectored vaccine induces neutralizing antibody response against Ebola virus. P. Younan, M. Iampietro and A. Bukreyev (2018). Protein phosphatase-1-targeting small molecule C31 inhibits Ebola virus replication. Antiviral Research 150:193-201. Gunn, A.L. H. Bisht, A. Roberts, L. Vogel, A. Bukreyev, P. Collins, B. Murphy, K. Subbarao, and B. Moss (2004). 86(19):10880-10884. *Co-corresponding author. A. I. Flyak, N. Kuzmina, C. D. Murin, C. Bryan, E. Davidson, P. Gilchuk, C. P. Gulka, P. A. Ilinykh, X. Shen, P. Ramanathan, K. Huang, H. Turner, M. L. Fusco, R. Lampley, N. Kose, H. King, G. Sapparapu, B. J. Doranz, T. G. Ksiazek, D. W. Wright, E. Ollmann Saphire, A. J. Virol. Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody. Investigation of mechanisms of "immune paralysis" caused by filoviruses. USA 99:16987-16991. L. Zhang, A. Bukreyev, C. Thompson, B. Watson, M. E. Peeples, P. L Collins, and R. J. Pickles (2005). Dis. Acad. This project will be focused on the innate immunity of bats. J. J. Virol. The Ebola interferon inhibiting domains attenuate and dysregulate cell-mediated immune responses. Recovery of infectious respiratory syncytial virus expressing an additional, foreign gene (1996). (2017). (2018). N. A. Kuzmina, P. Younan, P. Gilchuk, R. I. Santos, A. I. Flyak, P. A. Ilinykh, K. Huang,   N. M. Lubaki, P. Ramanathan, J. E. Crowe, Jr. and A. Bukreyev (2018). MCP M114.041129. B. The TLR4 antagonist Eritoran protects mice from lethal filovirus challenge. Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 and its targeting for the inhibition of viral transcription. C. Le Nouën S. Munir, S. Losq, C. C Winter, T. McCarty, D. A Stephany, K. L Holmes, A. Bukreyev, R. L. Rabin, P. L Collins, and U. J Buchholz (2009). Cross-reactive, neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk. M. Meyer, E. Huang, O. Yuzhakov, P. Ramanathan, G. Ciaramella, and A. Bukreyev (2018) Modified mRNA-based vaccines elicit robust immune responses and protect guinea pigs from Ebola virus disease. July 14, 2009. Disabling of lymphocyte immune response by Ebola Virus.PLOS Pathogens 14(4):e1006932. Antibody-mediated protective mechanisms induced by a trivalent parainfluenza-vectored ebolavirus vaccine. PLOS Pathogens PPATHOGENS-D-16-02653 published on 5/22/2017. The article was chosen for UTMB press releases on 12/01/2016. Trends in Microbiology 27(1):8-16. Academic Press. Acad. PLoS One 5(11):e15017. J. Clin. Interleukin 18 co-expression during respiratory syncytial virus infection results in enhanced disease mediated by natural killer cells. Paessler S, Fayzulin RZ, Anishchenko M, Greene IP, Weaver SC, Frolov I. Recombinant Sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic.J Virol 2003 77(17):9278-9286. (2017). PLOS Pathogens 14(8):e1007204. (2018). A. Bukreyev, Z. Huang, L. Yang, S. Elankumaran, M. St. Claire, B. R. Murphy, S. K. Samal, and P. L. Collins (2005). Journal of Infectious Diseases 218 (Suppl. (2017). J. Virol. A. I. Flyak, X. Shen, C. D. Murin, H. L. Turner, M. L. Fusco, R. Lampley, N. Kose, P. A. Ilinykh, N. Kuzmina, A. Branchizio, H. King, L. Brown, C. Bryan, E. Davidson, B. J. Doranz, J. C. Slaughter, G. Sapparapu, C. Klages, T. G. Ksiazek, E. O. Saphire, A. spotlight. Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection. A. Harker, D. C. P. Lee, Y. Yamaguchi, B. Wang, A. Bukreyev, P. L. Collins, J. S. Tregoning, and P. J. M. Openshaw. E. Ollmann Saphire , G. K. Lewis, G. Alter, A. Convener of the Vaccine and Viral Vectors III Workshop, 28th Annual Meeting of American Society for Virology, University of British Columbia, Vancouver, Canada. J. Infect. A. Bukreyev and P. Collins (2010). (2017). PLOS Pathogens 21(12):e1006031. Alexander Bukreyev: Associated Profiles ; Professor, Pathology and Microbiology & Immunology, UT Medical Branch at Galveston alexander.bukreyev@utmb.edu (409) 772-2829 Web Link Lab Webpage : Ebolavirus, Viruses, Respiratory Syncytial Viruses, Marburgvirus, Vaccines, Human Parainfulenza Virus 3, Viruses, Human Respiratory Syncytial Virus Z. Wec, C. L. Moyer, M. L. Fusco, P. A. Ilinykh, K. Huang, A. S. Wirchnianski, R. M. James, A. S. Herbert, S. Hui, E. Goodwin, K. A. Howell, S. Kailasan, M. J. Aman, L. M. Walker, J. M. Dye, A. Bukreyev, K. Chandran and E. Ollmann Saphire (2019). The UTMB Health MyChart Patient Support team is available 24/7 at (409) 772-4278. Departments of Pathology and Microbiology & Immunology Phone: (409) 772-2829 Lab: (409) 772-2831 Email: alexander.bukreyev@utmb.edu Bukreyev Laboratory Page J. H. Kuhn, G. K. Amarasinghe, C. F. Basler, S. Bavari, A. Bukreyev, K. Chandran, O. Kolnik, J. M. Dye, H. Ebihara, P. Formenty, R. Hewson, G. P. Kobinger, E. M. Leroy, E. Muhlberger, S. V. Netesov, J. L. Patterson, J. T. Paweska, S. J. Smither, A. Takada, J. S. Towner, V. E. Volchkov, V. Wahl-Jensen, and ICTV Report Consortium. Cell 164(3): 392-405. Genome sequencing of emerging viral pathogens, including paramyxoviruses and filoviruses. Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging pathogens. Journal of Virology JVI01845-18R1 in press. Mire, P.A. Review. A. Bukreyev, M. H. Skiadopoulos, B. R. Murphy, and P. L. Collins. Disabling of lymphocyte immune response by Ebola Virus. Ebolavirus chimerization for the development of a mouse model for screening of Bundibugyo-specific antibodies. 81(32):13105-13111. B. R. West, A. M. Meyer, E. Huang, O. Yuzhakov, P. Ramanathan, G. Ciaramella, and A. Bukreyev (2018) Modified mRNA-based vaccines elicit robust immune responses and protect guinea pigs from Ebola virus disease. Z. Wec, C. L. Moyer, M. L. Fusco, P. A. Ilinykh, K. Huang, A. S. Wirchnianski, R. M. James, A. S. Herbert, S. Hui, E. Goodwin, K. A. Howell, S. Kailasan, M. J. Aman, L. M. Walker, J. M. Dye, A. Bukreyev, K. Chandran and E. Ollmann Saphire (2019). The article was chosen for American Society for Microbiology press release in November 2007. Proteomics. J. Virol. A. I. Flyak, P. A. Ilinykh, C. D. Murin, T. Garron, X. Shen, M. L. Fusco, T. Hashiguchi, Z. Virology 377 (2):255-264. P. Ilinykh, M. Lubaki, S. Widen, L. A. Renn, T. C. Theisen, N. R. Rabin, T. Wood, and A. Bukreyev (2015) Different temporal effects of Ebola virus VP35 and VP24 on global gene expression in human dendritic cells. Mucosal parainfluenza virus-vectored vaccine against Ebola virus replicates in the respiratory tract of vector-immune monkeys and is immunogenic. Natl. Springer, ISBN 3-211-20671-X. A. Bukreyev and I. Belyakov (2002). In: Advances in virus research, 54:423-451. SHP Strategic Plan. 81(21):11560-11568. degree in electrical and computer engineering and physics from the University of Florida, Gainesville, FL, USA, in 2013. Innate immune response of bat and human cells to filoviruses: commonalities and distinctions. Viruses 9(5): E106. J. Virol. B. P. Gilchuk, N. Kuzmina, P. A. Ilinykh, K. Huang, B. M. Gunn, A. Bryan, E. Davidson, B. J. Doranz, H. L. Turner, M. L. Fusco, M. S. Bramble, N. A. Hoff, E. Binshtein, N. Kose, A. I. Flyak,, R. Flinko, C. Orlandi, R. Carnahan, E. H. Parrish, A. M. Sevy, R. G. Bombardi, P. K. Singh, P. Mukadi, J. J. Muyembe-Tamfum, M. D. Ohi, E. Ollmann Saphire , G. K. Lewis, G. Alter, A. Impairment of the CD8+ T cell response in lungs following respiratory versus non-respiratory viral infections. J. Virol. Expression of immunomodulating molecules by recombinant viruses: Can the immunogenicity of live virus vaccines be improved? Antiviral Research 158:288-302. Our research includes experiments in a BSL-2 labs and in BSL-4 labs of the Galveston National Laboratory. P. Gilchuk, D. Murin, J.C. Milligan, R.W. J. Virol. Natl. Journal of Infectious Diseases 218(Suppl. J. Virol. The article was chosen for Icahn School of Medicine at Mount Sinai press releases on 4/28/2016. 5): S418-S422. Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection. Our Lab focuses on investigation of the mechanisms of the high pathogenicity of viruses Ebola, Marburg and Lassa and development of vaccines and antibody treatments against these viruses. Recombinant Newcastle disease virus expressing a foreign viral antigen is attenuated and highly immunogenic in primates. Our research includes experiments in a BSL-2 lab and in BSL-4 labs of the Galveston National Laboratory. Proc. Ebola binding to Tim-1 on T-Lymphocytes induces a cytokine storm. A. Berzofsky, B. R. Murphy and P. L. Collins (2001). P. Gilchuk, D. Murin, J.C. Milligan, R.W. American Society for Virology Program Planning Committee, 2011-2013. Acad. 125(8): 3241-55. Runners' lab is de specialist voor lopers, traillopers en wandelaars. *Co-corresponding author. 125(8): 3241-55. Sci. 217(2):451-455. Can Ebola virus vaccines have universal correlates of protection? J. Harker, A. Godlee, J. L. Walhsten, D. C. P. Lee, L. Thorne, D. Sawant, J. S. Tregoning, R. Caspi, A. Bukreyev, P. L. Collins, and P. J. M. Openshaw (2010). Kirchdoerfer., K. M. Hastie, A. Sangha, J. Meiler, G. Alter, A. Bukreyev, J. E. Crowe, Jr., and E. Ollmann Saphire. Proteomics. Non-structural proteins 1 and 2 of respiratory syncytial virus suppress maturation of human dendritic cells. Feb 15, 2018, 11:03 AM by Mary Jo Singleton Immunity. 218 (Suppl. development of genetically modified filoviruses from the DNA-copies of their genomes and use of mini-genomes), immunological tools such as multi-parameter flow cytometry, and human immune cells and animal models. The National Institutes of Health Merit Award in Recognition of Outstanding Contributions and Efforts in Support of NIAID Mission. N. Freiberg, S. Nekhai, and A. Bukreyev (2014). J. S. Tregoning, B.L. S. Munir, C. Luongo, C. Le Nouen, U. J. Buchholz, P. L. Collins, and A. Bukreyev (2008). ACS Infectious Diseases 1(8): 380-387. Assymetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap. USA. J. M. DiNapoli, L. Yang, A. Suguitan Jr., S. Elankumaran, B. R. Murphy, S. K. Samal, P. L. Collins, and A. Bukreyev (2007). J. Infect. (2016). J. Virol. Nature Microbiology 3(6):670-677. Experimental evolution of viruses in bats. Journal of Infectious Diseases 218 (Suppl. mBio 8(5) e00845-17. The article was chosen for UTMB and the Vanderbilt University press releases on 1/21/2016, and was highlighted in Nature 529, 440. Dis. Expert Rev. The secreted form of the G glycoprotein of respiratory syncytial virus helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects of Fc receptor-bearing leucocytes. J. H. Kuhn. J. Invest. Protein phosphatase-1-targeting small molecule C31 inhibits Ebola virus replication. 5): S627-S635. A. W. Rimoin, A. Bukreyev*, and J. E. Crowe, Jr*. Dis. N. M. Lubaki, P. Ilinykh, C. Pietzsch, B. Tigabu, A. N. Freiberg, R. A. Koup, and A. Bukreyev (2013). P. A. Ilinykh, B. Tigabu, A. Ivanov, T. Ammosova,  Y. Obukhov, T. Garron, N. Kumari, D. Kovalskyy, M. O. Platonov, V. S. Naumchik,A. *Co-corresponding author. 84 (3):1489-1503. A. Bukreyev and P. Collins (2008). Mol. Staufen1 interacts with multiple components of the Ebola virus ribonucleoprotein and enhances viral RNA synthesis. What are the risks - hypothetical and observed - of recombination involving live vaccines and vaccine vectors based on nonsegmented negative strand RNA viruses? USA 110(14):5576-5581. Ward, A. W. Rimoin, A. Bukreyev*, and J. E. Crowe, Jr*. (2017). S. Netesov, S. Wagener, A. Bukreyev, L. Kolombet, D. Pobedimskaya, R. Hawley, I. Belyakov, Y. Remnev, E. Turin (2010). Cell 160(5) 893-903. The NS2 protein of human respiratory syncytial virus suppresses the cytotoxic T cell response as a consequence of suppressing the type I interferon response. Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 and its targeting for the inhibition of viral transcription. More antibody with less antigen: Can immunogenicity of attenuated live virus vaccines be improved? Journal of Infectious Diseases 218 (Suppl. P. L. Collins, A. Bukreyev, and B. R. Murphy (2008). State Research Center of Virology and Biotechnology "Vector", Koltsovo, Russia. Comparative immunology of bats as a reservoir of filoviruses (in collaboration with Dr. Chris Basler). 5): S327-S334. Cell 174(4):938-952. Sci. PLOS Pathogens 13(5):e1006397. P. Ilinykh, M. Lubaki, S. Widen, L. A. Renn, T. C. Theisen, N. R. Rabin, T. Wood, and A. Bukreyev (2015) Different temporal effects of Ebola virus VP35 and VP24 on global gene expression in human dendritic cells. J. Virol. Antibody repertoires to the same Ebola vaccine antigen are differentially affected by vaccine vectors. Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection. A single intranasal inoculation with a paramyxovirus-vectored vaccine protects guinea pigs against a lethal dose Ebola virus challenge. Assymetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap. Infection of ciliated cells by parainfluenza virus type 3 in an vitro model of human airway epithelium. The National Institute of Health Fellows Award for Research Excellence. P. Younan, M. Iampietro, A. Nishida, P. Ramanathan, R. I. Santos, M. Dutta, N. M. Lubaki, R. A. Koup, M. G. Katze, and A. Bukreyev. Gunn, A.L. Vaccine, 27 (10):1530-1539. Delivery to the lower respiratory tract is required for effective immunization with Newcastle disease virus-vectored vaccines intended for humans. J. Infect. (2015) Aerosolized Ebola vaccine protects primates and elicits lung-resident T-cell responses. The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains. 90(15):7567-83. The article was chosen for Lancet press release on 06/23/04 and the NIH press release on 06/24/04. Dr. Soong’s research focuses on New World cutaneous, mucosal and visceral leishmaniasis. Nonsegmented negative-strand viruses as vaccine vectors. Acad. Development of therapeutic human monoclonal antibody treatments for filoviruses, in collaboration with Dr. James Crowe, Jr. (Vanderbilt University). Altman, S. Hui, B.M. Virology, 385 (1):169-182. Firestone, M. St. Clair, W. R. Elkins, P. L. Collins, and B. R. Murphy (1999). July 20-24, 2013. Acad. *Co-corresponding authors. Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors. In 2017-2018, UTMB CLS graduates earned 100% ASCP Board of Certification one-year pass rate. Dive into the research topics where Alexander Bukreyev is active. 218 (Suppl. Most UTMB Health clinics offer on site laboratory services to conveniently meet your health care needs at the point of service. To get insight into these scietific topics, we are using molecular tools, including reverse genetics (i.e. J. Infect. 8(2) e00368-17. King, B. R. West, C. L. Moyer, P. Gilchuk, A. Flyak, P. A. Ilinykh, R. Bombardi, S. Hui, K. Huang, A. Bukreyev, J. E. Crowe, Jr. and E. Ollmann Saphire (2019). Immunity 49(2):363-374. Wang, J. U. McDonald, Y. Yamaguchi, J. B. Welcome to the Department of Anesthesiology, UTMB Health, UTMB.edu Together they form a unique fingerprint. A. Bukreyev, E. W. Lamirande, U. J. Buchholz, L. N. Vogel, W. R. Elkins, M. St. Clair, B. R. Murphy, K. Subbarao, and P. L. Collins (2004). USA 96:2367-2372. The article was chosen for UTMB and the Vanderbilt University press releases on 5/26/2015. Cell Host & Microbe 23(1):101-109. Biol. The article was chosen for Icahn School of Medicine at Mount Sinai press releases on 4/28/2016. J. Virol. J. Infect. Taxonomy of the order Mononegavirales: update 2018. Journal of Virology JVI00426-18R2 in press. P. A. Ilinykh, B. Tigabu, A. Ivanov, T. Ammosova,  Y. Obukhov, T. Garron, N. Kumari, D. Kovalskyy, M. O. Platonov, V. S. Naumchik, A. N. Freiberg, S. Nekhai, and A. Bukreyev (2014). The article was chosen for American Society of Microbiology and UTMB press releases on 09/26/2017. Op zoek naar Compressport Ultra-Trail Postural Top - UTMB 2020 voor heren? 1994. Note: Some of these articles require subscriptions. Our collaborators include Dr. James Crowe, Jr. (Vanderbilt University), Dr. Erica Ollmann Saphire (La Jolla Institute for Immunology), Dr. Galit Alter (Ragon Institute), Dr. Thomas Geisbert (UTMB), Dr. Raul Andino (UCSF), Moderna, Inc. and other groups. Antibody-mediated protective mechanisms induced by a trivalent parainfluenza-vectored ebolavirus vaccine. Ward, E. O. Saphire, A. Bukreyev*, and J. E. Crowe, Jr.* (2015) Mechanism of human antibody-mediated neutralization of Marburg virus. The University of Texas Medical Branch at Galveston, Graduate Training in Experimental Pathology, Pathology Residency & Fellowship Program, Paul Brindley Distinguished Professorship, Pathology Microscope Imaging Core Laboratory, 2018 DMT Conference UTMB Faculty & Staff Registration. 90(15):7567-83. In 2016, the UTMB Department of Clinical Laboratory Science implemented the first Doctorate in Clinical Laboratory Science (DCLS) program in Texas. Antibody-mediated protective mechanisms induced by a trivalent parainfluenza-vectored ebolavirus vaccine. Kang's Lab At Utmb is on Facebook. Non-commercial Partnership "Center of Modern Medical Technologies TEMPO". A. Bukreyev, S. S. Whitehead, C. Prussin, B. R. Murphy and P. L. Collins (2000). A contributor. 218 (Suppl. Respiratory syncytial virus interferon antagonist NS1 protein suppresses and skews the T lymphocyte response. P. Gilchuk, N. Kuzmina, P. A. Ilinykh, K. Huang, B. M. Gunn, A. Bryan, E. Davidson, B. J. Doranz, H. L. Turner, M. L. Fusco, M. S. Bramble, N. A. Hoff, E. Binshtein, N. Kose, A. I. Flyak,, R. Flinko, C. Orlandi, R. Carnahan, E. H. Parrish, A. M. Sevy, R. G. Bombardi, P. K. Singh, P. Mukadi, J. J. Muyembe-Tamfum, M. D. Ohi, E. Ollmann Saphire , G. K. Lewis, G. Alter, A. The cysteine-rich region and secreted form of the attachment G glycoprotein of respiratory syncytial virus enhance the cytotoxic T lymphocyte response despite lacking MHC class I-restricted epitopes. J. Infect. Development of therapeutic human monoclonal antibody treatments. MyChart should only be used for non-urgent matters; it should not be used in emergencies. Proc. Z. Wec, P. J. Halfmann, J. M. Brannan, A. S. Herbert, X. Qio et al. 363(9427):2122-2127. Advances in the development of vaccines against Marburg and Ebola viruses. The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains. J. Virol. Characterization of antibody responses to virus infections in humans. Respiratory syncytial virus can tolerate an intergenic sequence of at least 160 nucleotides with little effect on transcription or replication in vitro and in vivo. Shieh, B. R. Murphy, P. L. Collins, and A. Sanchez (2007). Turner, T. Alkutkar, R. Flinko, C. Orlandi, R. Carnahan, R. Nargi, R.G. A. Rialdi, L. Campisi, N. Zhao, A. C. Lagda, C. Pietzsch, J. S. Ho, L. Martinez-Gil, R. Fenouil, X. Chen, M. Edwards, G. Metreveli, S. Jordan, Z. Peralta, C. Muniz-Fontela, N. Bouvier, M. Merad, J. Jin, M. Weirauch, S. Heinz, C. Benner, H. van Bakel, C. Basler, A. Garcia-Sastre, A. Bukreyev, and I. Marazzi. T. S. Postler, A. N. Clawson, G. K. Amarasinghe, C. F. Basler, S. Bavari, M. Benko, K. R. Blasdell, T. Briese, M. J. Buchmeier, A. Bukreyev et al. Staufen1 interacts with multiple components of the Ebola virus ribonucleoprotein and enhances viral RNA synthesis. Op zoek naar Compressport Ultra-Trail 180g Racing Hoodie - UTMB 2020 voor heren? The article was chosen for American Society of Microbiology and UTMB press releases on 09/26/2017. A. Bukreyev, M. H. Skiadopoulos, J. McAuliffe, B. R. Murphy, P. L. Collins and A. C. Schmidt (2002). Dis. Bats seem to be natural reservoirs for coronaviruses and now, new research from the University of Texas Medical Branch (UTMB) at Galveston indicates the small mammals are also kind hosts to Ebola. J. Virol. J. L. B. Institution: University of Texas Medical Branch at Galveston. A. I. Flyak, N. Kuzmina, C. D. Murin, C. Bryan, E. Davidson, P. Gilchuk, C. P. Gulka, P. A. Ilinykh, X. Shen, P. Ramanathan, K. Huang, H. Turner, M. L. Fusco, R. Lampley, N. Kose, H. King, G. Sapparapu, B. J. Doranz, T. G. Ksiazek, D. W. Wright, E. Ollmann Saphire, A. J. DiNapoli, A. Kotelkin, L. Yang, B. R. Murphy, S. Samal, P. L. Collins, and A. Bukreyev (2007). Respiratory Syncytial Virus Infection Sensitizes Cells to Apoptosis Mediated by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL). J. Virol. P. Luthra, J. Naidoo, C. A. Pietzsch, M. R. Edwards, S. De, S. Khadka, M. Anantpadma, R. A. Davey, A. Bukreyev, J. M. Ready and C. F. Basler (2018). Virol. The article was chosen for J. Virol. B. Tigabu, P. Ramanathan, A. Ivanov, X. Lin, P. A. Ilinykh, C. S. Parry, A. N. Freiberg, S. Nekhai and A. Bukreyev (2018). July 17, 2010. J. Virol. A. Bukreyev, A. Marzi, F. Feldmann, L. Zhang, L. Yang, J. M. Ward, D. Dorward, R. J. Pickles, B. R. Murphy, H. Feldmann, and P. L. Collins (2009). M. Iampietro, R. I. Santos, N. M. Lubaki and A. Bukreyev (2018). Epub on Apr 28, 2016. Convener of the Filoviruses Workshop, 30th Annual Meeting of American Society for Virology, University of Minnesota, Minneapolis, Minnesota. *Co-senior authors. Review article. J. Fang, C. Pietzsch, P. Ramanathan, R. I. Santos, P. A. Ilinykh, M. A. Garcia-Blanco, A. Bukreyev and S. S. Bradrick (2018). Ward, A. Bukreyev*, and J. E. Crowe*, Jr. (2018). Effects of human respiratory syncytial virus, metapneumovirus, paramyxovirus type 3, and influenza A virus on the ability of human dendritic cells to activate autologous CD4 T cells. Proc. development of genetically modified filoviruses from the DNA-copies of their genomes and use of mini-genomes), immunological tools such as multi-parameter flow cytometry, and human immune cells and animal models. Innate immune response of bat and human cells to filoviruses: commonalities and distinctions. Nature Communications 10 (1):1788. 90(8): 3890-901. Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection. 90(15):7567-83. Master of Science in Clinical Laboratory Sciences. Proc. A. Bukreyev, I. M. Belyakov, G. A. PLOS Pathogens 14(8):e1007204. The secreted G protein of human respiratory syncytial virus (RSV) antagonizes antibody-mediated restriction of replication involving macrophages and complement. A. Bukreyev, U. J. Buchholz, K. A. Dave, E. L. Norris, C. L. Wright, K. M. Spann, P. L. Collins and J. J. Gorman (2012). Natur Wissenschaften 86:8-17. A. Berzofsky, P. L. Collins, and A. Bukreyev (2006). P. L. Collins and A. Bukreyev (2007). Multifunctional pan-ebolavirus antibodies recognize a site of broad vulnerability on the ebolavirus glycoprotein. As a Clinical Laboratory Scientist, you become a behind-the-scenes detective in the health care industry, accurately and precisely performing laboratory procedures to provide crucial information in diagnosing, preventing, and treating diseases. N. A. Kuzmina, P. Younan, P. Gilchuk, R. I. Santos, A. I. Flyak, P. A. Ilinykh, K. Huang,   N. M. Lubaki, P. Ramanathan, J. E. Crowe, Jr.and A. Bukreyev (2018). Ebola binding to Tim-1 on T-Lymphocytes induces a cytokine storm. J. Virol. L. B. Dive into the research topics where Thomas Ksiazek is active. *Co-senior authors. mBio 9(5): e01771-18. P. A. Ilinykh, J. Graber, N. A. Kuzmina, K. Huang, T. G. Ksiazek, J. E. Crowe, Jr. and A. Bukreyev (2018). Technologies TEMPO '' avian influenza virus protect against virus challenge in monkeys L. Collins and A. (. 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